Are You Wasting Money on NAD Supplements?

Dr. Darshan Shah
May 20, 2025

Most people think energy loss, slower recovery, and poor sleep are just part of getting older. But what if the real problem is happening on a cellular level, and you’re missing the key molecule that powers it all?

Here’s the truth:
Every cell in your body depends on NAD to produce energy, repair damage, fight inflammation, and keep your systems running smoothly. But daily stressors like overnutrition, alcohol, UV exposure, infection, and even basic immune function are constantly depleting your NAD supply.

If your NAD system is under attack (and for most people, it is), your body is working harder just to keep up.

The good news? You can support your NAD system the right way, with science-backed strategies, not hype.

3 NAD Truths You Need To Know:

1️⃣ Not all NAD boosters are created equal
NAD, NMN, NR, niacin… the options are confusing. But here’s what matters: NR (nicotinamide riboside) is the most direct, research-backed precursor that your cells can actually absorb and use. Many NMN supplements on the market aren’t even real NMN—or worse, they’re contaminated with harmful byproducts.

2️⃣ IV NAD might not be your best bet
IV NAD sounds promising—but NAD outside the cell can trigger an immune response, which is why IV NAD infusions often feel uncomfortable. NR, on the other hand, bypasses this issue and safely boosts NAD where it matters: inside your cells.

3️⃣ Your NAD system depletes faster than you think
Every time your body fights an infection, repairs DNA, responds to inflammation, or handles oxidative stress, it burns through NAD. Boosting your NAD supply isn’t just about energy—it’s about resilience and recovery at the cellular level.

Episode 63: Charles Brenner: NAD, Energy, and Longevity: The Secret Nobody Told You About

In the latest episode of Extend, I’m joined by Dr. Charles Brenner—the leading NAD scientist and the discoverer of NR (nicotinamide riboside). We break down what NAD actually does, the real difference between NR, NMN, niacin, and NAD, and why your energy, recovery, and long-term health depend on supporting this system.

We also discuss:

✅ Why your NAD system is under constant attack
✅ The proven clinical benefits of NR for inflammation, immune resilience, and recovery
✅ The problem with most NMN supplements on the market
✅ The truth about IV NAD and why it feels terrible for many people
✅ Where the science stands on NAD, longevity, and disease prevention

If you care about protecting your energy, supporting your recovery, and living a longer, healthier life… this is the episode for you.

Listen now on Apple Podcasts or Spotify.